Salt Dependence of A-Form RNA Duplexes: Structures and Implications.

ABSTRACT: The biological functions of RNA range from gene regulation through catalysis and depend critically on its structure and flexibility. Conformational variations of flexible, non-base-paired components, including RNA hinges, bulges, or single-stranded tails, are well documented. Recent work has also identified variations in the structure of ubiquitous, base-paired duplexes found in almost all functional RNAs. Duplexes anchor the structures of folded RNAs, and their surface features are recognized by partner molecules. To date, no consistent picture has been obtained that describes the range of conformations assumed by RNA duplexes. Here, we apply wide angle, solution X-ray scattering (WAXS) to quantify these variations, by sampling length scales characteristic of helical geometries under diff

SUBMITTER: Chen YL 

PROVIDER: S-EPMC7068736 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature