Dentate gyrus volume deficit in schizophrenia.

ABSTRACT:

Background

Schizophrenia is associated with robust hippocampal volume deficits but subregion volume deficits, their associations with cognition, and contributing genes remain to be determined.

Methods

Hippocampal formation (HF) subregion volumes were obtained using FreeSurfer 6.0 from individuals with schizophrenia (n = 176, mean age ± s.d. = 39.0 ± 11.5, 132 males) and healthy volunteers (n = 173, mean age ± s.d. = 37.6 ± 11.3, 123 males) with similar mean age, gender, handedness, and race distributions. Relationships between the HF subregion volume with the largest between group difference, neuropsychological performance, and single-nucleotide polymorphisms were assessed.

Results

This study found a significant group by region interaction on hippocampal subregion vol

SUBMITTER: Nakahara S 

PROVIDER: S-EPMC7068799 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature