Commercial 4-dimensional echocardiography for murine heart volumetric evaluation after myocardial infarction.

ABSTRACT:

Background

Traditional preclinical echocardiography (ECHO) modalities, including 1-dimensional motion-mode (M-Mode) and 2-dimensional long axis (2D-US), rely on geometric and temporal assumptions about the heart for volumetric measurements. Surgical animal models, such as the mouse coronary artery ligation (CAL) model of myocardial infarction, result in morphologic changes that do not fit these geometric assumptions. New ECHO technology, including 4-dimensional ultrasound (4D-US), improves on these traditional models. This paper aims to compare commercially available 4D-US to M-mode and 2D-US in a mouse model of CAL.

Methods

37 mice underwent CAL surgery, of which 32 survived to a 4 week post-operative time point. ECHO was completed at baseline, 1 week, and 4 weeks after CAL

SUBMITTER: Rutledge C 

PROVIDER: S-EPMC7068892 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature