Linked-read sequencing identifies abundant microinversions and introgression in the arboviral vector Aedes aegypti.

ABSTRACT:

Background

Aedes aegypti is the principal mosquito vector of Zika, dengue, and yellow fever viruses. Two subspecies of Ae. aegypti exhibit phenotypic divergence with regard to habitat, host preference, and vectorial capacity. Chromosomal inversions have been shown to play a major role in adaptation and speciation in dipteran insects and would be of great utility for studies of Ae. aegypti. However, the large and highly repetitive genome of Ae. aegypti makes it difficult to detect inversions with paired-end short-read sequencing data, and polytene chromosome analysis does not provide sufficient resolution to detect chromosome banding patterns indicative of inversions.

Results

To characterize chromosomal diversity in this species, we have carried out deep Illumina sequencing o

SUBMITTER: Redmond SN 

PROVIDER: S-EPMC7068900 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature