Identification of molecules associated with response to abatacept in patients with rheumatoid arthritis.

ABSTRACT:

Background

Abatacept (ABA) is a biological disease-modifying antirheumatic drug (bDMARD) for rheumatoid arthritis (RA). The aim of this study was to identify molecules that are associated with therapeutic responses to ABA in patients with RA.

Methods

Peripheral blood was collected using a PAX gene Blood RNA kit from 45 bDMARD-naïve patients with RA at baseline and at 6 months after the initiation of ABA treatment. Gene expression levels of responders (n = 27) and non-responders (n = 8) to ABA treatment among patients with RA at baseline were compared using a microarray. The gene expression levels were confirmed using real-time quantitative polymerase chain reaction (RT-qPCR).

Results

Gene expression analysis revealed that the expression levels of 218 genes were signif

SUBMITTER: Yokoyama-Kokuryo W 

PROVIDER: S-EPMC7068901 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature