Psychiatric morbidity and poor follow-up underlie suboptimal functional and survival outcomes in Huntington's disease.

ABSTRACT: BACKGROUND:Huntington's disease (HD), an inherited, often late-onset, neurodegenerative disorder, is considered to be a rare, orphan disease. Research into its genetic correlates and services for those affected are inadequate in most low-middle income countries, including India. The apparent 'incurability' often deters symptomatic and rehabilitative care, resulting in poor quality of life and sub-optimal outcomes. There are no studies assessing disease burden and outcomes from India. METHODS:We attempted to evaluate individuals diagnosed to have HD at our tertiary-care center between 2013 and 2016 for clinical symptoms, functionality, mortality, follow up status through a structured interview, clinical data from medical records and UHDRS-TFC scoring. RESULTS:Of the 144 patients, 25% were u

SUBMITTER: Ratna N 

PROVIDER: S-EPMC7068943 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature