An immune-centric exploration of BRCA1 and BRCA2 germline mutation related breast and ovarian cancers.

ABSTRACT:

Background

BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The prominent tumor mutation burden (TMB) in hereditary breast and ovarian cancers in this cohort was not correlated with high global immune activity in their microenvironments. More information is needed about the relationship between genomic instability, phenotypes and immune microenvironments of these hereditary tumors in order to find appropriate markers of immune activity and the most effective anticancer immune strategies.

Methods

Mining and statistical analyses of the original DNA and RNA sequencing data and The Cancer Genome Atlas data were performed. To

SUBMITTER: Przybytkowski E 

PROVIDER: S-EPMC7068944 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature