Mutational landscape differences between young-onset and older-onset breast cancer patients.

ABSTRACT:

Background

The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, suggesting an important role for somatic mutations. This study investigated genomic differences between young- and older-onset breast tumours.

Methods

In this study we characterized the mutational landscape of 89 young-onset breast tumours (≤40 years) and examined differences with 949 older-onset tumours (> 40 years) using data from The Cancer Genome Atlas. We examined mutated genes, mutational load, and types of mutations. We used complementary R packages "deconstructSigs" and "SomaticSignatures" to extract mutational signatures. A recursively partitioned mixt

SUBMITTER: Mealey NE 

PROVIDER: S-EPMC7068998 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature