Magnetic core-shell nanowires as MRI contrast agents for cell tracking.

ABSTRACT: BACKGROUND:Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents. RESULTS:This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core-shell nanowires were evaluated at 1.5 T, revealing a high performance as T2 contrast agents. Different levels of oxidation and various surface coatings were tested at 7 T. Their effects on the T2 contrast were reflected

SUBMITTER: Martinez-Banderas AI 

PROVIDER: S-EPMC7069006 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature