Survival and mortality of elderly men with localized prostate cancer managed with primary androgen deprivation therapy or by primary observation.

ABSTRACT:

Background

Androgen deprivation therapy (ADT) remains a primary treatment for localized prostate cancer (PCa) even though there is no evidence that its use is beneficial in the absence of curative treatment.

Methods

Men aged ≥70 years (n = 16,534) diagnosed with localized PCa from 1985 to 2014 and managed either with primary observation or ADT in the absence of curative treatment were included. The cases were identified from the population-based Finnish Cancer Registry. We estimated the standardized mortality ratios (SMR) for overall mortality by treatment group. We determined the relative risk (RR) of PCa-specific mortality (PCSM) and other-cause mortality between the two treatment groups. Survival was determined using the life table method. Two age groups (70-79 years and 

SUBMITTER: Seikkula H 

PROVIDER: S-EPMC7069023 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature