Drug use and torsades de pointes cardiac arrhythmias in Sweden: a nationwide register-based cohort study.

ABSTRACT:

Objective

To study the occurrence of torsades de pointes (TdP) ventricular tachycardia in relation to use of drugs labelled with TdP risk, using two nationwide Swedish registers.

Design

Prospective register-based cohort study.

Setting

Entire Sweden.

Participants

Persons aged ≥18 years prescribed and dispensed any drug classified with TdP risk during 2006-2017, according to CredibleMeds. Persons with a registered TdP diagnosis during the study period, using drugs labelled with known (TdP 1), possible (TdP 2) or conditional (TdP 3) risk at the incident of TdP were examined.

Primary outcome measures

Occurrence of TdP in relation to exposure rates for individual drugs with TdP risk.

Secondary outcome measures

Concurrent use of more than one TdP-labell

SUBMITTER: Danielsson B 

PROVIDER: S-EPMC7069257 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature