Sex differences in the efficacy of antihypertensive treatment in preventing cardiovascular outcomes and reducing blood pressure: protocol for a systematic review and meta-analysis.

ABSTRACT:

Introduction

Hypertension is a leading cause of mortality worldwide and its prevalence is expected to rise over the next decade. Sex differences exist in the epidemiology and pathophysiology of hypertension. It is well established that antihypertensive treatment can significantly reduce the risk for stroke and other cardiovascular disease events. However, it remains unclear whether this effect is dependent on sex. In this protocol, we outlined a systematic review and meta-analysis to evaluate the effects of antihypertensive therapy in (1) reducing blood pressure and (2) preventing cardiovascular morbidity and mortality outcomes for each sex separately.

Methods and analysis

The following electronic databases will be searched: Medline, Embase, The Cochrane Library, PubMed, Cum

SUBMITTER: Gasbarrino K 

PROVIDER: S-EPMC7069325 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature