Tin thiocarbonohydrazone complexes: synthesis, crystal structures and biological evaluation.

ABSTRACT: In this article, three organotin complexes formulated as [(Me)₂Sn(H₂L¹)] (1), [(Ph)₂Sn(H₂L¹)]·MeOH (2) and [(Me)₂Sn(HL²)(OAc)]₄(Me)₂O (3) (H₄L¹ = bis(2-hydroxybenzaldehyde) thiocarbohydrazone and H₂L² = bis(2-acetylpyrazine) thiocarbonohydrazone) have been synthesized and structurally characterized. Growth inhibition assays indicated that both the proligands and the three complexes are capable of showing anticancer activity against the human hepatocellular carcinoma HepG2 cells with H₂L² and complex 3 showing much higher cytotoxic potential. Subsequent toxicity studies on normal QSG7701cel

SUBMITTER: Wang J 

PROVIDER: S-EPMC7069364 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature