Group-based Trajectory Models to Assess Quality of INR Control and Its Association With Clinical Outcomes.

ABSTRACT:

Background

The Time in Therapeutic Range (TTR) is the gold-standard measure used to assess the quality of oral anticoagulation with vitamin K antagonists. However, TTR is a static measure, and International Normalized Ratio (INR) control is a dynamic process. Group-based Trajectory Models (GBTM) can address this dynamic nature by classifying patients into different trajectories of INR control over time.

Objectives

The objective of this study was to assess the quality of INR control in a population-based cohort of new users of vitamin K antagonist with a diagnosis of atrial fibrillation using GBTM.

Methods

We classified patients into different trajectories according to their propensity for being adequately anticoagulated over their first year of treatment using GBTM, a

SUBMITTER: Garcia-Sempere A 

PROVIDER: S-EPMC7069412 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature