Candida albicans enhances meropenem tolerance of Pseudomonas aeruginosa in a dual-species biofilm.

ABSTRACT:

Background

Pseudomonas aeruginosa is an opportunistic bacterium that infects the airways of cystic fibrosis patients, surfaces of surgical and burn wounds, and indwelling medical devices. Patients are prone to secondary fungal infections, with Candida albicans being commonly co-isolated with P. aeruginosa. Both P. aeruginosa and C. albicans are able to form extensive biofilms on the surfaces of mucosa and medical devices.

Objectives

To determine whether the presence of C. albicans enhances antibiotic tolerance of P. aeruginosa in a dual-species biofilm.

Methods

Single- and dual-species biofilms were established in microtitre plates and the survival of each species was measured following treatment with clinically relevant antibiotics. Scanning electron microscopy and c

SUBMITTER: Alam F 

PROVIDER: S-EPMC7069478 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature