Learning partial differential equations for biological transport models from noisy spatio-temporal data.

ABSTRACT: We investigate methods for learning partial differential equation (PDE) models from spatio-temporal data under biologically realistic levels and forms of noise. Recent progress in learning PDEs from data have used sparse regression to select candidate terms from a denoised set of data, including approximated partial derivatives. We analyse the performance in using previous methods to denoise data for the task of discovering the governing system of PDEs. We also develop a novel methodology that uses artificial neural networks (ANNs) to denoise data and approximate partial derivatives. We test the methodology on three PDE models for biological transport, i.e. the advection-diffusion, classical Fisher-Kolmogorov-Petrovsky-Piskunov (Fisher-KPP) and nonlinear Fisher-KPP equations. We show that

SUBMITTER: Lagergren JH 

PROVIDER: S-EPMC7069483 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature