Two-component assembly of recognition-encoded oligomers that form stable H-bonded duplexes.

ABSTRACT: A new family of recognition-encoded oligomers that form stable duplexes in chloroform have been prepared. Monomer building blocks composed of dialdehydes functionalised with either a trifluoromethylphenol or phosphine oxide H-bond recognition unit were prepared. The dialdehydes were coupled with diamines by imine formation and then reduction to give homo-oligomers between one and three recognition units in length. Duplex formation was characterised by 19F and 1H NMR titration experiments in toluene and in chloroform. For duplexes formed between length complementary H-bond donor and acceptor homo-oligomers, an order of magnitude increase in stability was observed for every base-pair added to the duplex in chloroform. The effective molarity for the intramolecular H-bonds responsible for zipp

SUBMITTER: Gabrielli L 

PROVIDER: S-EPMC7069511 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature