Prognostic implications of human papillomavirus status for patients with non-oropharyngeal head and neck squamous cell carcinomas.

ABSTRACT:

Purpose

We examined overall survival in a large cohort of patients with human papillomavirus (HPV)-positive and HPV-negative non-oropharyngeal squamous cell carcinoma of the head and neck (non-OPSCC).

Methods

Patients diagnosed with non-OPSCC and known HPV status were identified in the National Cancer Database (NCDB). Multivariate logistic regression was applied to examine factors associated with HPV status. Multivariate analysis was utilized to determine factors correlated with overall survival. Propensity score-weighted Kaplan-Meier estimation was used to adjust for confounders in survival analyses. Multiple imputation method was used for sensitivity analysis.

Results

We identified 19,993 non-OPSCC patients with 5070 being positive for HPV in the NCDB. Median follow

SUBMITTER: Ko HC 

PROVIDER: S-EPMC7069668 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature