In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation.

ABSTRACT: Vascularized composite allotransplantation (VCA) encompasses face and limb transplantation, but as with organ transplantation, it requires lifelong regimens of immunosuppressive drugs to prevent rejection. To achieve donor-specific immune tolerance and reduce the need for systemic immunosuppression, we developed a synthetic drug delivery system that mimics a strategy our bodies naturally use to recruit regulatory T cells (T_reg) to suppress inflammation. Specifically, a microparticle-based system engineered to release the T_reg-recruiting chemokine CCL22 was used in a rodent hindlimb VCA model. These "Recruitment-MP" prolonged hindlimb allograft survival indefinitely (>200 days) and promoted donor-specific tolerance. Recruitment-MP treatment enriched T_reg pop

SUBMITTER: Fisher JD 

PROVIDER: S-EPMC7069700 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature