Complete assignment of Ala, Ile, Leu^ProS, Met and Val^ProS methyl groups of the protruding domain from human norovirus GII.4 Saga.

ABSTRACT: Attachment of human noroviruses to histo blood group antigens (HBGAs) is thought to be essential for infection, although how this binding event promotes infection is unknown. Recent studies have shown that 60% of all GII.4 epidemic strains may undergo a spontaneous post-translational modification (PTM) in an amino acid located adjacent to the binding pocket for HBGAs. This transformation proceeds with an estimated half-life of 1-2 days under physiological conditions, dramatically affecting HBGA recognition. The surface-exposed position of this PTM and its sequence conservation suggests a relevant role in immune escape and host-cell recognition. As a first step towards the understanding of the biological implications of this PTM at atomic resolution, we report the complete assignment of met

SUBMITTER: Muller-Hermes C 

PROVIDER: S-EPMC7069894 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature