Different receptor mechanisms underlying phytocannabinoid- versus synthetic cannabinoid-induced tetrad effects: Opposite roles of CB₁ /CB₂ versus GPR55 receptors.

ABSTRACT:

Background and purpose

Cannabis or cannabinoids produce characteristic tetrad effects-analgesia, hypothermia, catalepsy and suppressed locomotion, which are believed to be mediated by the activation of cannabinoid CB₁ receptors. Given recent findings of CB₂ and GPR55 receptors in the brain, we examined whether these receptors are also involved in cannabinoid action.

Experimental approach

We compared Δ⁹ -tetrahydrocannabinol (Δ⁹ -THC)-, WIN55212-2-, or XLR11-induced tetrad effects between wild-type (WT) and each genotype of CB₁ -, CB₂ - or GPR55-knockout (KO) mice and then observed the effects of antagonists of these receptors on these tetrad effects in WT mice.

Key results

Systemic administration of Δ

SUBMITTER: Wang XF 

PROVIDER: S-EPMC7070166 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature