Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice.

ABSTRACT:

Background and purpose

Naringenin, a flavonoid compound with strong anti-inflammatory activity, attenuated non-alcoholic fatty liver disease (NAFLD) induced by a methionine-choline deficient (MCD) diet in mice. However, the mechanisms underlying this suppression of inflammation and NAFLD remain unknown.

Experimental approach

WT and NLRP3^-/- mice were fed with MCD diet for 7 days to induce NAFLD and were given naringenin by gavage at the same time. in vitro experiments used HepG2 cells, primary hepatocytes, and Kupffer cells (KCs) stimulated by LPS or LPS plus oleic acid (OA).

Key results

Treating WT mice with naringenin (100 mg·kg^-1 ·day^-1 ) attenuated hepatic lipid accumulation and inflammation in the livers of mice given the MCD diet

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7070172 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature