Haemodynamic effects of the flavonoid quercetin in rats revisited.

ABSTRACT:

Background and purpose

The flavonoid quercetin increased the in vitro potency of the α₁ -antagonist tamsulosin to reduce phenylephrine-dependent arterial contractions by 10-fold. To examine if this supplement-drug interaction luxates hypotensive and orthostatic events in vivo, several set of studies were conducted in spontaneously hypertensive (SHR) and normotensive (Wistar Kyoto [WKY]) rats.

Experimental approach

First, in rats pretreated with quercetin or its vehicle, responses to phenylephrine and tamsulosin were examined. Second, tamsulosin-induced changes in renal, mesenteric, hindquarter and carotid conductance were compared in quercetin- and vehicle-treated rats instrumented with Doppler flow probes. Animals were also placed on a tilt table to record region

SUBMITTER: Vrolijk MF 

PROVIDER: S-EPMC7070173 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature