Long-Term Adverse Effects of Oxidative Stress on Rat Epididymis and Spermatozoa.

ABSTRACT: Oxidative stress is a common culprit of several conditions associated with male fertility. High levels of reactive oxygen species (ROS) promote impairment of sperm quality mainly by decreasing motility and increasing the levels of DNA oxidation. Oxidative stress is a common feature of environmental pollutants, chemotherapy and other chemicals, smoke, toxins, radiation, and diseases that can have negative effects on fertility. Peroxiredoxins (PRDXs) are antioxidant enzymes associated with the protection of mammalian spermatozoa against oxidative stress and the regulation of sperm viability and capacitation. In the present study, we aimed to determine the long-term effects of oxidative stress in the testis, epididymis and spermatozoa using the rat model. Adult male rats were treated with ter

SUBMITTER: Wu PY 

PROVIDER: S-EPMC7070312 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature