Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na_v 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects.

ABSTRACT: Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special interest in the Na_v 1.7 subtype, which is expressed predominantly in nociceptive and sympathetic neurons. The aim was to demonstrate analgesic properties of a potent selective Na_v 1.7 sodium channel blocker, PF-05089771, alone and concomitantly with pregabalin in healthy subjects using a battery of human evoked pain models. This was a double-blind, double-dummy, randomized, placebo-controlled, five-period cross-over study with PF-05089771 alone and PF-05089771 concomitantly with pregabalin as treatment arms with pregabalin,

SUBMITTER: Siebenga P 

PROVIDER: S-EPMC7070789 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature