Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins.

ABSTRACT: Chromatin structure and function, and consequently cellular phenotype, is regulated in part by a network of chromatin-modifying enzymes that place post-translational modifications (PTMs) on histone tails. These marks serve as recruitment sites for other chromatin regulatory complexes that 'read' these PTMs. High-quality chemical probes that can block reader functions of proteins involved in chromatin regulation are important tools to improve our understanding of pathways involved in chromatin dynamics. Insight into the intricate system of chromatin PTMs and their context within the epigenome is also therapeutically important as misregulation of this complex system is implicated in numerous human diseases. Using computational methods, along with structure-based knowledge, we have designed a

SUBMITTER: Rectenwald JM 

PROVIDER: S-EPMC7070942 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature