Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis.

ABSTRACT: Nasopharyngeal carcinoma (NPC) is a common cancer found in the nasopharynx with high metastatic and invasive nature. Increasing evidences have identified the critical role of gene therapy in NPC treatment. Hence, this study was designed to identify specific gene markers that affected NPC progression through gene expression profile analysis. NPC-related gene expression data set gene set enrichment (GSE)53819 were retrieved and analyzed to screen out differentially expressed genes (DEGs), followed by determination of their expression in noncancerous tissues and NPC specimens. Next, weighted gene co-expression network analysis (WGCNA) was conducted on DEGs to obtain tumor-associated gene modules. Genes in those modules were intersected with DEGs for gene ontology and Kyoto Encyclopedia of Gen

SUBMITTER: Xue K 

PROVIDER: S-EPMC7070980 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature