Design, Synthesis, and Antimicrobial Activities of 1,2,3-Triazole Glycoside Clickamers.

ABSTRACT: Bacterial resistance remains a significant threat and a leading cause of death worldwide, despite massive attempts to control infections. In an effort to develop biologically active antibacterial and antifungal agents, six novel aryl-substituted-1,2,3-triazoles linked to carbohydrate units were synthesized through the Cu(I)-catalyzed azide-alkyne cycloaddition CuAAC of substituted-arylazides with a selection of alkyne-functionalized sugars. The chemical structures of the new derivatives were verified using different spectroscopic techniques. The novel clicked 1,2,3-triazoles were evaluated for in vitro antibacterial activity against Gram-positive Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa, and the obtained results were compared with the activity of the ref

SUBMITTER: El Malah T 

PROVIDER: S-EPMC7071105 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature