Safety Assessment of Bacteroides Uniformis CECT 7771, a Symbiont of the Gut Microbiota in Infants.

ABSTRACT: The formulation of next-generation probiotics requires competent preclinical studies to show their efficacy and safety status. This study aims to confirm the safety of the prolonged oral use of Bacteroides uniformis CECT 7771, a strain that protected against metabolic disorders and obesity in preclinical trials, in a sub-chronic 90 day trial in animals. The safety assessment was conducted in male and female Wistar rats (n = 50) administered increasing doses (10⁸ CFU/day, 10⁹ CFU/day, or 10¹⁰ CFU/day) of B. uniformis CECT 7771, 10¹⁰ CFU/day of B. longum ATCC 15707^T, which complies with the qualifying presumption of safety (QPS) status of the EU, or vehicle (placebo), as the control. Pancreatic, liver, and kid

SUBMITTER: Gomez Del Pulgar EM 

PROVIDER: S-EPMC7071458 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature