Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts.

ABSTRACT: The identification of cerebral microinfarctions with magnetic resonance imaging (MRI) and histological methods remains challenging in aging and dementia. Here, we matched pathological changes in the microvasculature of cortical cerebral microinfarcts to MRI signals using single 100 μm-thick histological sections scanned with ultra-high-resolution 11.7 T MRI. Histologically, microinfarcts were located in superficial or deep cortical layers or transcortically, compatible with the pattern of layer-specific arteriolar blood supply of the cerebral cortex. Contrary to acute microinfarcts, at chronic stages the core region of microinfarcts showed pallor with extracellular accumulation of lipofuscin and depletion of neurons, a dense meshwork of collagen 4-positive microvessels with numerous string

SUBMITTER: Yilmazer-Hanke D 

PROVIDER: S-EPMC7071593 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature