Factors Moderating the Association Between Cannabis Use and Psychosis Risk: A Systematic Review.

ABSTRACT: Increasing evidence indicates a relationship between cannabis use and psychosis risk. Specific factors, such as determinants of cannabis use or the genetic profile of cannabis users, appear to moderate this association. The present systematic review presents a detailed and up-to-date literature overview on factors that influence the relationship between cannabis use and psychosis risk. A systematic search was performed according to the PRISMA guidelines in MEDLINE and Embase, and 56 studies were included. The results show that, in particular, frequent cannabis use, especially daily use, and the consumption of high-potency cannabis are associated with a higher risk of developing psychosis. Moreover, several genotypes moderate the impact of cannabis use on psychosis risk, particularly those

SUBMITTER: van der Steur SJ 

PROVIDER: S-EPMC7071602 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature