Fecal microbiota characteristics of Chinese patients with primary IgA nephropathy: a cross-sectional study.

ABSTRACT:

Background

Growing evidence has shown that the gut-renal connection and gut microbiota dysbiosis play a critical role in immunoglobulin A nephropathy (IgAN). However, the fecal microbiome profile in Chinese patients with IgAN remains unknown. A cross-sectional study was designed for the first time to investigate the fecal microbiota compositions in patients with primary IgAN in China and to evaluate the relationship between the fecal microbiome and IgAN clinical presentation.

Methods

Fecal samples were collected from 17 IgAN patients and 18 age-, sex-, and body mass index-matched healthy controls, and bacterial DNA was extracted for 16S ribosomal RNA gene sequencing targeting the V3-V4 region.

Results

Fecal samples from the IgAN patients and healthy controls showed di

SUBMITTER: Hu X 

PROVIDER: S-EPMC7071635 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature