A peripheral neutrophil-related inflammatory factor predicts a decline in executive function in mild Alzheimer's disease.

ABSTRACT:

Background

Studies suggest a role of the innate immune system, including the activity of neutrophils, in neurodegeneration related to Alzheimer's disease (AD), but prospective cognitive data remain lacking in humans. We aimed to investigate the predictive relationship between neutrophil-associated inflammatory proteins in peripheral blood and changes in memory and executive function over 1 year in patients with AD.

Methods

Participants with AD were identified from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Neutrophil gelatinase-associated lipocalin (NGAL), myeloperoxidase (MPO), interleukin-8 (IL-8), macrophage inflammatory protein-1 beta (MIP-1β), and tumor necrosis factor (TNF) were assayed by luminex immunofluorescence multiplex assay at baseline. Confirmator

SUBMITTER: Bawa KK 

PROVIDER: S-EPMC7071641 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature