Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis.

ABSTRACT:

Background

The disorder of copper homeostasis is linked with disease and developmental defects, and excess copper_nanoparticles (CuNPs) and ion (Cu²⁺) will induce developmental malformation and disease in organisms. However, little knowledge is available regarding its potential regulation mechanisms, and little study links excess copper with retinal developmental malformation and disease.

Methods

Embryos were stressed with copper (CuNPs and Cu²⁺), and cell proliferation and apoptosis assays, reactive oxygen species (ROS) and endoplasmic reticulum (ER) signaling detections, and genetic mutants cox17^-/- and atp7a^-/- application, were used to evaluate copper induced retinal developmental malformation and the underlying genetic and bio

SUBMITTER: Zhao G 

PROVIDER: S-EPMC7071659 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature