Mechanical load-induced H₂S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1.

ABSTRACT:

Background

Tooth movement is a unique bone remodeling process induced by mechanical stimulation. Macrophages are important in mediating inflammatory processes during mechanical load-induced tooth movement. However, how macrophages are regulated under mechanical stimulation remains unclear. Mesenchymal stem cells (MSCs) can modulate macrophage polarization during bone remodeling. Hydrogen sulfide (H₂S) can be produced by MSCs and have been linked to bone homeostasis. Therefore, this study aimed to investigate whether H₂S contributed to periodontal ligament stem cell (PDLSC)-regulated macrophage polarization and bone remodeling under mechanical stimulation.

Methods

An experimental mechanical load-induced tooth movement animal model was established. Change

SUBMITTER: He D 

PROVIDER: S-EPMC7071778 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature