Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle.

ABSTRACT: A distinct population of Foxp3⁺CD4⁺ regulatory T (Treg) cells promotes repair of acutely or chronically injured skeletal muscle. The accumulation of these cells depends critically on interleukin (IL)-33 produced by local mesenchymal stromal cells (mSCs). An intriguing physical association among muscle nerves, IL-33⁺ mSCs, and Tregs has been reported, and invites a deeper exploration of this cell triumvirate. Here we evidence a striking proximity between IL-33⁺ muscle mSCs and both large-fiber nerve bundles and small-fiber sensory neurons; report that muscle mSCs transcribe an array of genes encoding neuropeptides, neuropeptide receptors, and other nerve-related proteins; define muscle mSC subtypes that express both IL-33 and the receptor for the

SUBMITTER: Wang K 

PROVIDER: S-EPMC7071852 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature