Representation of distinct reward variables for self and other in primate lateral hypothalamus.

ABSTRACT: The lateral hypothalamus (LH) has long been implicated in maintaining behavioral homeostasis essential for the survival of an individual. However, recent evidence suggests its more widespread roles in behavioral coordination, extending to the social domain. The neuronal and circuit mechanisms behind the LH processing of social information are unknown. Here, we show that the LH represents distinct reward variables for "self" and "other" and is causally involved in shaping socially motivated behavior. During a Pavlovian conditioning procedure incorporating ubiquitous social experiences where rewards to others affect one's motivation, LH cells encoded the subjective value of self-rewards, as well as the likelihood of self- or other-rewards. The other-reward coding was not a general consequenc

SUBMITTER: Noritake A 

PROVIDER: S-EPMC7071915 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature