Zebrafish Avatars towards Personalized Medicine-A Comparative Review between Avatar Models.

ABSTRACT: Cancer frequency and prevalence have been increasing in the past decades, with devastating impacts on patients and their families. Despite the great advances in targeted approaches, there is still a lack of methods to predict individual patient responses, and therefore treatments are tailored according to average response rates. "Omics" approaches are used for patient stratification and choice of therapeutic options towards a more precise medicine. These methods, however, do not consider all genetic and non-genetic dynamic interactions that occur upon drug treatment. Therefore, the need to directly challenge patient cells in a personalized manner remains. The present review addresses the state of the art of patient-derived invitro and invivo models, from organoids to mouse and zebrafish Av

SUBMITTER: Costa B 

PROVIDER: S-EPMC7072137 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature