Misregulation of ELK1, AP1, and E12 Transcription Factor Networks Is Associated with Melanoma Progression.

ABSTRACT: Melanoma is among the most malignant cutaneous cancers and when metastasized results in dramatically high mortality. Despite advances in high-throughput gene expression profiling in cancer transcriptomic studies, our understanding of mechanisms driving melanoma progression is still limited. We present here an in-depth bioinformatic analysis of the melanoma RNAseq, chromatin immunoprecipitation (ChIP)seq, and single-cell (sc)RNA seq data to understand cancer progression. Specifically, we have performed a consensus network analysis of RNA-seq data from clinically re-grouped melanoma samples to identify gene co-expression networks that are conserved in early (stage 1) and late (stage 4/invasive) stage melanoma. Overlaying the fold-change information on co-expression networks revealed several

SUBMITTER: Singh K 

PROVIDER: S-EPMC7072154 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature