Granulins Regulate Aging Kinetics in the Adult Zebrafish Telencephalon.

ABSTRACT: Granulins (GRN) are secreted factors that promote neuronal survival and regulate inflammation in various pathological conditions. However, their roles in physiological conditions in the brain remain poorly understood. To address this knowledge gap, we analysed the telencephalon in Grn-deficient zebrafish and identified morphological and transcriptional changes in microglial cells, indicative of a pro-inflammatory phenotype in the absence of any insult. Unexpectedly, activated mutant microglia shared part of their transcriptional signature with aged human microglia. Furthermore, transcriptome profiles of the entire telencephali isolated from young Grn-deficient animals showed remarkable similarities with the profiles of the telencephali isolated from aged wildtype animals. Additionally, 50%

SUBMITTER: Zambusi A 

PROVIDER: S-EPMC7072227 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature