N6-Methyladenosine Regulates the Expression and Secretion of TGFβ1 to Affect the Epithelial-Mesenchymal Transition of Cancer Cells.

ABSTRACT: N6-methyladenosine (m⁶A) is the most abundant modification on eukaryotic mRNA, which regulates all steps of the mRNA life cycle. An increasing number of studies have shown that m⁶A methylation plays essential roles in tumor development. However, the relationship between m⁶A and the progression of cancers remains to be explored. Here, we reported that transforming growth factor-β (TGFβ1)-induced epithelial-mesenchymal transition (EMT) was inhibited in methyltransferase-like 3 (METTL3) knockdown (Mettl3^Mut/-) cells. The expression of TGFβ1 was up-regulated, while self-stimulated expression of TGFβ1 was suppressed in Mettl3^Mut/- cells. We further revealed that m⁶A promoted TGFB1 mRNA decay, but impaired TGFB1 translation progre

SUBMITTER: Li J 

PROVIDER: S-EPMC7072279 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature