How Quickly Do Proteins Fold and Unfold, and What Structural Parameters Correlate with These Values?

ABSTRACT: The correlations between the logarithm of the unfolding rate of 108 proteins and their structural parameters were calculated. We showed that there is a good correlation between the logarithm of folding and unfolding rates (0.79) and protein stability and unfolding rate (0.79). Thus, the faster the protein folds, the faster it unfolds. Folding and unfolding rates are higher for the proteins with two-state kinetics, in comparison with the proteins with multi-state kinetics. At the same time, two-state bacterial proteins folds and unfolds two orders of magnitude faster than two-state eukaryotic proteins, and multi-state bacterial proteins folds and unfolds slower than multi-state eukaryotic proteins. Despite the fact that the folding rates of thermophilic and mesophilic proteins are close, th

SUBMITTER: Glyakina AV 

PROVIDER: S-EPMC7072309 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature