Genomic Signature of the Standardized Uptake Value in ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer.

ABSTRACT: The standardized uptake value (SUV), an indicator of the degree of glucose uptake in ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used for predicting the clinical behavior of malignant tumors. However, its characteristics have been insufficiently explored at the genomics level. Here, we aim to identify genomic signatures reflecting prognostic SUV characteristics in breast cancer (BRC). Through integrative genomic profiling of 3710 BRC patients, including 254 patients who underwent preoperative FDG-PET, we identified an SUV signature, which showed independent clinical utility for predicting BRC prognosis (hazard ratio [HR] 1.27, 95% confidence interval [CI] = 1.12 to 1.45, p = 2.23 × 10^-4). The risk subgroups classified by the signatur

SUBMITTER: Kim SK 

PROVIDER: S-EPMC7072341 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature