Impact of Age-Related Genetic Differences on the Therapeutic Outcome of Papillary Thyroid Cancer.

ABSTRACT: The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide. PTC is the most common type of differentiated thyroid cancer and usually shows good prognosis. However, some PTC is driven to advanced stage by epithelial-mesenchymal transition (EMT)-mediated drug resistance, which is particularly noticeable in pediatric patients. There are limited options for systemic treatment, necessitating development of new clinical approaches. Here, we aimed to clarify genetic differences due to age of patients with PTC, and thereby aid in developing novel therapeutics. Patients with biochemically and histologically confirmed PTC were included in this study. PTC cells were acquired from young and older patients showing drug resistance, and were compared via microarray analysis. Cellula

SUBMITTER: Kim SM 

PROVIDER: S-EPMC7072359 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature