Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism.

ABSTRACT: The processes involved in cell growth are extremely complicated even for a single cell organism such as Escherichia coli, while the relationship between growth rate and cell size is simple. We aimed to reveal the systematic link between them from the aspect of the genome-scale metabolic network. Since the growth rate reflects metabolic rates of bacteria and the cell size relates to phospholipid synthesis, a part of bacterial metabolic networks, we calculated the cell length from the cardiolipin synthesis rate, where the cardiolipin synthesis reaction is able to represent the phospholipid metabolism of Escherichia coli in the exponential growth phase. Combined with the flux balance analysis, it enables us to predict cell length and to examine the quantitative relationship between cell lengt

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7072380 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature