Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges.

ABSTRACT: Colorectal cancer (CRC) is a leading cause of death among cancer patients. This heterogeneous disease is characterized by alterations in multiple molecular pathways throughout its development. Mutations in RAS, along with the mismatch repair gene deficiency, are currently routinely tested in clinics. Such biomarkers provide information for patient risk stratification and for the choice of the best treatment options. Nevertheless, reliable and powerful prognostic markers that can identify "high-risk" CRC patients, who might benefit from adjuvant chemotherapy, in early stages, are currently missing. To bridge this gap, genomic information has increasingly gained interest as a potential method for determining the risk of recurrence. However, due to several limitations of gene-based signatures

SUBMITTER: Koncina E 

PROVIDER: S-EPMC7072488 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature