Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer.

ABSTRACT: The mechanisms that drive ductal carcinoma in situ (DCIS) progression to invasive cancer are not clear. Studying DCIS progression in humans is challenging and not ethical, thus necessitating the characterization of an animal model that faithfully resembles human disease. We have characterized a canine model of spontaneous mammary DCIS and invasive cancer that shares histologic, molecular, and diagnostic imaging characteristics with DCIS and invasive cancer in women. The purpose of the study was to identify markers and altered signaling pathways that lead to invasive cancer and shed light on early molecular events in breast cancer progression and development. Transcriptomic studies along the continuum of cancer progression in the mammary gland from healthy, through atypical ductal hyperplas

SUBMITTER: Mohammed SI 

PROVIDER: S-EPMC7072653 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature