Probing Carbon Utilization of Cordyceps militaris by Sugar Transportome and Protein Structural Analysis.

ABSTRACT: Beyond comparative genomics, we identified 85 sugar transporter genes in Cordyceps militaris, clustering into nine subfamilies as sequence- and phylogenetic-based functional classification, presuming the versatile capability of the fungal growths on a range of sugars. Further analysis of the global gene expression patterns of C. militaris showed 123 genes were significantly expressed across the sucrose, glucose, and xylose cultures. The sugar transporters specific for pentose were then identified by gene-set enrichment analysis. Of them, the putative pentose transporter, CCM_06358 gene, was highest expressed in the xylose culture, and its functional role in xylose transport was discovered by the analysis of conserved structural motifs. In addition, a battery of molecular mode

SUBMITTER: Sirithep K 

PROVIDER: S-EPMC7072658 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature