Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors.

ABSTRACT: Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the most widely practiced treatment. However, it has several limitations. As an alternative approach, human pluripotent stem cells (hPSCs) can provide an unlimited source of pancreatic cells that have the ability to secrete insulin in response to a high blood glucose level. However, the determination of the appropriate pancreatic lineage candidate for the purpose of cell therapy for the treatment of diabetes is still debated. While hPSC-derived beta cells are perceived as the ultimate candidate, their efficiency needs further improvement in order to obtain a sufficient number of glucose responsive beta cells f

SUBMITTER: Memon B 

PROVIDER: S-EPMC7072676 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature