miR-1272 Exerts Tumor-Suppressive Functions in Prostate Cancer via HIP1 Suppression.

ABSTRACT: The development of novel therapies or the improvement of currently used approaches to treat prostate cancer (PCa), the most frequently diagnosed male tumor in developed countries, is an urgent need. In this regard, the functional characterization of microRNAs, molecules shown to regulate a number of cancer-related pathways, is instrumental to their possible clinical exploitation. Here, we demonstrate the tumor-suppressive role of the so far uncharacterized miR-1272, which we found to be significantly down-modulated in PCa clinical specimens compared to normal tissues. Through a gain-of-function approach using miRNA mimics, we showed that miR-1272 supplementation in two PCa cell models (DU145 and 22Rv1) reverted the mesenchymal phenotype by affecting migratory and invasive pro

SUBMITTER: Rotundo F 

PROVIDER: S-EPMC7072756 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature